Rapid detection of H1N1 avian influenza virus detection is not reliable

Officials estimate that since early April there had been infected with H1N1 bird flu up to 1 million Americans a lot. Its symptoms, which is similar to the seasonal flu, which may include fever, headache, coughing, sneezing, sore throat, muscle or joint pain for up to one week. Who has been working with a considerable number of infected people also reported diarrhea and vomiting. Antiviral drugs such as Tamiflu and Relenza have been found effective treatment and reduce the duration of the disease, from one or two days in general. However, in order to play the biggest role, it must in the management of symptoms 12 to 48 hours. This may be a problem, taking into account the traditional identification of cell culture, the virus may take several days, and rapid detection tests can provide results within 30 minutes or less are not sure H1N1 virus, more than half the time, according to a new government report .

The U.S. Centers for Disease Control (CDC) for research and testing has proved to contain the use of laboratory testing, from the three companies: Binax Inc., Becton, Dickinson Company, and three Quidel’s influenza virus clinical samples Quidel best performance of the test and found that 69 percent of infections. In flow cytometry, Dickinson trial testing 49-fold, Binax test found that 40 percent. All tests found that seasonal influenza H1N1 viruses better than that. “These findings suggest that, despite the positive (rapid detection test) results can be made to deal with decisions, negative results do not exclude new influenza (H1N1) virus infection,” the author writes with.

These findings are not entirely unexpected. A clinical virology to a recent study found that a test found that only 10 percent of the H1N1 virus infection, and the second found that only 40%. In the “absence of a ton of rapid detection of influenza” can pick a more advanced laboratory culture, long?????Christensen said that in microbiology, virology and molecular diagnostics, director of the north shore of Long Island Jewish Medical System in Lake Success, while in New York, in a letter in June New England Journal of Medicine, the U.S. Navy researchers have described the Quidel tests of sensitivity, and noted that they found that only half of the infections picked up a more sensitive technology.

However, the test makers say their product is helpful, if used properly. Clinical and regulatory affairs senior vice president of Quidel Corporation John Tamerius said Quidel’s QuickVue influenza virus A-and B-type influenza antigen detection tests can be found 80 percent of infections, if the specimen from the management of the nose to do swabs taken directly to the self-correct, and if this test is given at an early stage disease, when more of the viral infection process. “When used properly these tests, performance is very, very good,” Tamerius said.

Last week, the Center for Disease Control and Prevention updated guidance, requiring careful examination to rely on fear of negative readings may prevent antiviral treated patients, especially those high-risk, such as pregnant women and those with asthma or other conditions of the basic medical health-care providers such as heart disease and diabetes.

By: jagat  :  Filed Under Alerts & Outbreaks

FDA’s Warning On Electronic Cigarettes

The U.S. Food and Drug Administration warned the U.S. not to use electronic cigarettes, because they contain cancer-causing chemicals, including one of the other toxins in the antifreeze compounds. However, they did not ban the sale of these smoke-free devices.

Cigarettes and other similar electronic products, online sales, as well as kiosks in shopping malls throughout the United States scores also. These devices can be a hot gas, feels like a real smoke nicotine spray. (Also nicotine, free version of the electronic cigarette.) Now, FDA has tested two of these devices: Njoy products and equipment of smoking everywhere.who is a lawyer, is also a director of FDA’s drug evaluation and research departments to adhere to the office, said: “Our product review so far, we have found to be illegal.” However, the U.S. FDA is still not carrying prohibited goods such equipment, because there is pending litigation on the FDA jurisdiction over the issue of electronic cigarette.

So why hold a press conference on the problem? Joshua Sharfstein, Ph.D., and FDA Principal Deputy Commissioner, said: “We think it is important, although there are lawsuits, we are considering the options, no one can right the U.S. FDA’s position on this issue causes confusion.”

At the news conference, an FDA analyst Benjamin Westenberger to describe test from the E, two brands of 19 different cartridges, the U.S. FDA facilities in St. Louis cigarettes. They found that, in these tests:
• All of the bullets, but was marked as a non-nicotine, whereas the actual substance of the addiction.
• that are considered to have low, medium, high, or the actual amount of nicotine in varying degrees of nicotine was significantly cartridges.
• The ink cartridges a positive, there is a toxic antifreeze ingredient, diethylene glycol.
• light-emitting device is a “tobacco-specific nitrosamines are carcinogenic.”
• The device is also suspected to have fired the tobacco specific impurities harmful to humans.
FDA’s press conference also features also issued strong opposition to the use of electronic cigarettes, some experts warn:
• Dr. Jonathan Weinikefu, who is the President of the Association of tobacco Pediatrics, American Academy of Sciences warned that these types of products seems to be specific, in order to have attractive children. He said that these devices can be nicotine addiction, children, eventually they are smoking.
• Dr. Matthew McKenna, who is the CDC’s Office on Smoking and Health pointed out that electronic cigarettes can also be in the environment is smoke-free, thereby weakening the anti-smoking efforts with health benefits.
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• Dr. Jonathan who is also a global health at the University of Southern California, director of the Institute warned that the e-cigarette nicotine is not the same, the delivery of the approval by the FDA in order to help people quit smoking equipment. He also pointed out that he has not confirmed the benefits of electronic cigarette, but the risk is also very clear.

Since 2008, the U.S. Food and Drug Administration has been trying to prevent their entry into the United States, e-cigarette. To date, approximately 50 volume of refuse, but has yet to stop sales and distribution of electronic cigarettes. In March 2009, Canada, a complete ban on the use of these devices.

Manufacturers and distributors of the E – cigarettes argue that their equipment safer than smoking real cigarettes, thus reducing the hazards of smoking. Some people even suggest that their products to help people quit smoking tobacco products.

FDA has rejected these demands, because these devices can provide synthesis of nicotine dose, without the approval of these agencies as they know the safety of drug delivery devices. It is also no evidence that these devices can safely help people stop smoking, but they have significant potential to attract them to the candy and fruit flavors, new smokers.

The electronic in many sizes and shapes to cigarettes. Many of them look like a long cigarette, while others can look like a pipe or cigars. They are still at work, basically the same way:
• User inhaled through a mouthpiece.
• Air Flow sensor is triggered, will open a small battery-powered heater.
• heater and then a small casket where evaporation of liquid nicotine, but also activate the light, in the “lit” end of the electronic cigarette. Users can also select a nicotine cartridge is free of charge.
• heater will also ink vaporization of propylene glycol (PEG). Polyethylene glycol is a stage in which the smoke from the elements.
• The user then get very close to the hot gas jet of tobacco smoke.
• When the user emitted, there is a polyethylene glycol vapor cloud looks like smoke. Steam will quickly dissipate.
• in the electronic cigarette contains no tobacco products. Even nicotine cigarettes are integrated in the electronics.
The device is usually retail for 100-200 yuan. The filled cartridge packaging different prices depending on nicotine. There are liquids to do it-yourself cartridge sales. Each cartridge is filled with several purposes.

The equipment manufacturers say they do not have health requirements for their products. Craig, Brad, who is InLife electronic cigarette company’s president, and pointed out that tobacco is bad for you because often, your non-smoking thing assuages nicotine habit, the need to reduce bad for you.

“In our product you have a nicotine or no nicotine, polyethylene glycol, and some seasoning. Your cigarette nicotine, polyethylene glycol, 4,000 chemicals and 43 carcinogens. My supporters or harm reduction. The people of have the right and choice, should be allowed to let them. ”

Others believe that, as a deceptive way to make people addicted to nicotine such equipment. One of them is that these people Michael Erickson, Ph.D., who is of public health in Atlanta, Georgia State University and the Center for Disease Control and Prevention Office of Smoking and Health, former director, director of the Institute.

“I do not see any evidence that people from tobacco cigarettes, electronic cigarettes or other smokeless tobacco products switch. If you look at how the market smokeless products, and their things, sometimes you can not smoke for sale. The implication is that you nicotine may increase rather than reduce smoking, “Eriksson said.

By: jagat  :  Filed Under Alerts & Outbreaks